The SARS CoV-2 is an RNA virus that is prone to mutation. The laboratories have to conduct genetic analysis to detect the changes in the form of the virus. Different SARS CoV-2 have been identified, including B.1.1.7, B.1.351, and P.1 variants. They are spreading very fast across the world. 

It is also being said that SARS CoV-2 can be more dangerous than the previous strains of the coronavirus. It is due to its higher chance of transmissibility and increase in the disease severity. Also, the Delta variant of SARS CoV-2 has more cases of getting transmitted faster. However, it can still not be speculated that these variants can rise to the third wave in India and worldwide. 

A new variant of SARS CoV-2 was detected in India called  Delta Variant. This variant is the most dominant variant of the recent surge of the covid cases in the country, and it remains one of the most rapidly rising lineages across the world. 

The Covid 19 B.1.1.7 has carried many mutations capable of changing or entirely deleting the amino acids in the viral proteins. N510Y is considered one of the critical mutations in the  Receptor Binding Domain of spike protein in position 501. It is where the amino acids have been replaced. 

There is one more key mutation in B.1.1.7 at the 681 of the spike protein. It is where the proline is replaced by histidine. 

Are These Mutations Resistant To The Current Authorized Vaccines?

The Covid 19 vaccine has been rolled all over the world. Access to a safe and effective vaccine is crucial to ending the Covid 19 pandemic. According to the  WHO, safe and effective vaccines are considered to be an effective tool. But for the foreseeable future, everyone needs to continue wearing masks, cleaning their hands, and maintaining a physical distance. 

According to a preprint released on Medrxiv on 8th February 2021, it was estimated that the vaccine based on the mRNA-based BioNTech and Pfizer vaccine reduced the viral load by about 1.6 fold to about 20 fold in the patients infected by the SARS CoV-2. 

A preprint released in The Lancet suggested that the AstraZeneca vaccine’s effectiveness against the B.1.1.7 is similar to that of the Non-B. 1.1.7 lineages. The study conducted by them also found out that the neutralization capacity of the vaccine against B.1.1.7 was ninefold lower than that of the Non-B. 1.1.7 lineages. 

According to the WHO, being vaccinated doesn’t mean that people worldwide can throw out the caution and put themselves and others at the risk of getting infected by the virus. Noncompliance to the acceptable  Covid behavior can increase the probabilities of the foremost speculated third wave.

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